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Accumulating evidence suggests that the regulation of ferroptosis can change the level of OS in cardiomyocytes or vascular cells, resulting in cardiomyocyte injury, cardiac hypertrophy and HF through the interaction between ROS with ERS (Kamoshita et al., 2014

Institute of Medicine defines Estimated Average Requirements (EARs), Recommended Dietary Allowances (RDAs), Adequate Intakes (AIs), and Tolerable upper intake levels (ULs) collectively referred to as Dietary Reference Intakes (DRIs)

Serious episodes can be associated with extensive muscle cell damage and necrosis, and electrocardiographic (EKG) abnormalities associated with hypokalemia, such as ST and T wave changes, premature ventricular complexes (PVCs), first degree heart block, prolonged QT intervals, and even ventricular fibrillation (337)

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